Senior Medical Director
Company: Maze Therapeutics
Location: South San Francisco
Posted on: February 16, 2026
|
|
|
Job Description:
Job Description Job Description The Opportunity Lead strategy.
Drive innovation. Transform lives. Maze Therapeutics is seeking a
Senior Medical Director to lead the clinical development strategy
for our APOL1 program, an innovative approach targeting a key
genetic driver of chronic kidney disease. In this highly visible
leadership role, you will design and oversee early-stage trials,
guide cross-functional teams, and ensure alignment with Maze's
mission to deliver transformative medicines. You'll engage with
scientific thought leaders, patient advocacy groups, and global
stakeholders to shape development plans and accelerate progress.
This is an opportunity to combine your medical expertise with
strategic vision to make a lasting impact on patients living with
kidney disease. In addition to our APOL1 program, Maze Therapeutics
has an exciting pipeline focused on renal, cardiac, and metabolic
diseases, including a second precision medicine for kidney disease
that is following closely behind APOL1. This role offers the
opportunity to play a fundamental part in advancing medical
breakthroughs that have the potential to transform many lives. This
position reports to the Head of Clinical Development. The Impact
You'll Have Lead the design, execution, and analysis of clinical
trials for the APOL1 program and other early-stage clinical assets
at Maze Author and review clinical-regulatory documents, including
protocols and amendments, informed consents, study reports, and
SAPs Prepare and deliver scientific presentations and other
communication materials for internal and external stakeholders,
including investigators and other Maze collaborators. Engage with
scientific thought leaders and patient advocacy groups to gain
insights to inform clinical development plans and build awareness
and enthusiasm for the Maze pipeline assets. Partner with Clinical
Development Operations to identify and select study investigators
and sites and build strong professional relationships with study
investigators. Partner with Clinical Development Operations to
identify, select, and oversee vendors and CROs to support program
needs. Develop and integrate timelines and budgets for clinical
activities with overall company timelines and goals, in close
coordination with project management, CMC, nonclinical development,
regulatory affairs, and other stakeholders. As a Senior Medical
Director, we also expect our leaders to demonstrate the following
Leadership Competencies: Communication and Influence Role models
clear communication and open two-way conversations. Reinforces an
environment where people feel heard and their opinions are valued.
Inspires followership despite differing initial opinions. Teamwork
and Collaboration Champions collaboration and connection across
Maze. Establishes team norms and expectations. Seeks opportunities
to spotlight team and individual contributions in public forums.
Execution and Results Develops recommendations to seize on
opportunities and mitigate obstacles that could impact long-term
success. Coaches others on resource management and work
distribution/delegation. Aligns work to Maze's strategy mission and
vision. Develop Others and Self Develops staff capabilities to
handle delegation of responsibilities. Encourages staff to develop
and execute personal stretch goals. Identifies and recommends ways
to increase inclusive leadership. What We're Looking For MD with 6
years of drug development industry experience. Board
eligibility/certification and clinical experience in internal
medicine and/or pediatrics. Additional clinical or research
experience in nephrology or cardiometabolic diseases is preferred.
Experience as a clinical study medical monitor Experience with the
preparation and submission of scientific publications, study
protocols, Investigator Brochures, and other clinical-regulatory
documents. Experience in the planning and oversight of early-stage
and/or registration-enabling clinical development programs
including CRO and site selection and relationship building with
investigators/site study staff, patient advocacy groups, and other
third parties Demonstrated knowledge and experience in the design
and conduct of clinical trials and clinical data analysis and
interpretation, particularly Phase 2 trials. Experience leading a
cross-functional study team. Committed to nurturing relationships
with investigators, site study staff, patient advocacy groups, and
other third parties to support the clinical programs and broader
Maze objectives. Exceptional organizational, analytical, and
communication skills, enabling you to translate corporate
objectives into actionable plans that consistently deliver
high-quality data on time and within budget. A positive and
enthusiastic disposition, adaptability to changing environments,
and unwavering personal and ethical standards in pursuit of
corporate goals. Willingness to travel domestically and
internationally (up to 20%) for vendor visits, industry
conferences, regulatory meetings, advisory boards, and other
essential gatherings. About Maze Therapeutics Maze Therapeutics is
a clinical-stage biopharmaceutical company harnessing the power of
human genetics to develop novel, small molecule precision medicines
for patients living with renal, cardiovascular and related
metabolic diseases, including obesity. The company is advancing a
pipeline using its Compass platform, which allows it to identify
and characterize genetic variants in disease and then link those
variants to the biological pathways that drive disease in specific
patient groups through a process it refers to as variant
functionalization. The company's pipeline is led by two wholly
owned lead programs, MZE829 and MZE782, each of which represents a
novel precision medicine-based approach for chronic kidney disease.
Maze is based in South San Francisco. Our People Maze is comprised
of a team of passionate and creative professionals committed to
discovering and delivering transformative medicines to patients
suffering from both rare and common genetic diseases. We are
fostering a culture that encourages vision, initiative and the
development of talent. Our supportive work environment inspires
creative thinking and freedom of expression, resulting in a
stimulating atmosphere where people enjoy coming to work. While we
have a passion for advanced science and pride ourselves on
excellence in execution, ultimately, everything we do is about
patients. Our Core Values Further Together – Our path is paved with
challenges, but with resilience and a team-first mentality, we'll
achieve our mission. Impact Obsessed – We embrace the bold, take
calculated risks, and learn from our mistakes to improve the lives
of others. Stand True – Our integrity is foundational; it guides us
no matter the obstacle. The expected annual salary range for
employees located in the San Francisco Bay Area is $338,000 to
$412,000. Additionally, this position is eligible for an annual
performance bonus. Maze performs position-based compensation
benchmarking to industry market data to ensure we pay competitive
wages. Determination of starting salary will depend upon a variety
of job-related factors, which may include professional experience,
skills, and job location. The expected salary range for this role
may be modified in the future. Maze offers a robust benefits
package to our eligible employees including competitive medical,
dental, and vision insurance, mental health offerings, equity
incentive plan, 401(k) program with employer match and a generous
holiday and PTO policy. LI-Hybrid
Keywords: Maze Therapeutics, Ceres , Senior Medical Director, Science, Research & Development , South San Francisco, California
